| |
Acute
systemic poisoning by TBT has never been reported
in humans, though tainted seafood consumption
is an obvious exposure route(57). The World Health
Organization using fish consumption figures of
15 and 150 g day-1, a value for TBT of 1 ug kg-1
for residues in fish, and an average human body
mass of 60 kg, proposed the following safety margins
based on immune endpoints(58) (Table 4.2a).
|
Table
4.2a Safety Margins for Intake of TBT
|
| Fish
consumption (g Day-1) |
Estimated
Daily TBT Intake (ug kg-1) |
Safety
Margin Based on Immune Parameters |
| 15 |
0.25 |
2500 |
| 150 |
2.5 |
250 |
No
tissues analysed in this baseline Study had TBT
concentrations as high as 1 ug kg-1. Based on
WHO safety margins, consumption of the biota that
did contain TBT, should not pose a significant
health risk to human consumers. It should be noted,
however, that rates of consumption can differ
widely amongst different consumer groups and safety
margins may need to be adjusted accordingly.
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